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Largest And Main Artery Of The Circulatory System

Another major cardiovascular disease involves the creation of a clot, called a "thrombus". These can originate in veins or arteries. Deep venous thrombosis, which mostly occurs in the legs, is one cause of clots in the veins of the legs, particularly when a person has been stationary for a long time. These clots may embolise, meaning travel to another location in the body. The results of this may include pulmonary embolus, transient ischaemic attacks, or stroke.

In the systemic circulation, the left ventricle pumps oxygen-rich blood into the main artery (aorta). The blood travels from the main artery to larger and smaller arteries and into the capillary network. There the blood drops off oxygen, nutrients and other important substances and picks up carbon dioxide and waste products. The blood, which is now low in oxygen, is collected in veins and travels to the right atrium and into the right ventricle.

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About 98.5% of the oxygen in a sample of arterial blood in a healthy human, breathing air at sea-level pressure, is chemically combined with hemoglobin molecules. About 1.5% is physically dissolved in the other blood liquids and not connected to hemoglobin. The hemoglobin molecule is the primary transporter of oxygen in mammals and many other species

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Cardiovascular diseases may also be congenital in nature, such as heart defects or persistent fetal circulation, where the circulatory changes that are supposed to happen after birth do not. Not all congenital changes to the circulatory system are associated with diseases, a large number are anatomical variations. The function and health of the circulatory system and its parts are measured in a variety of manual and automated ways.

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The primary function of the heart is to serve as a muscular pump propelling blood into and through vessels to and from all parts of the body. The arteries, which receive this blood at high pressure and velocity and conduct it throughout the body, have thick walls that are composed of elastic fibrous tissue and muscle cells. The arterial tree—the branching system of arteries—terminates in short, narrow, muscular vessels called arterioles, from which blood enters simple endothelial tubes (i.e., tubes formed of endothelial, or lining, cells) known as capillaries.

The heart itself is supplied with oxygen and nutrients through a small "loop" of the systemic circulation and derives very little from the blood contained within the four chambers.

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